Discovery of new G-quadruplex binding chemotypes.
نویسندگان
چکیده
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2014